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Autocom (シュペルカ) (November 24, 1977 – ) is a Japanese rock band founded in Kagoshima in 1980 by Takao Osawa.  .Regulatory T-cells in the human myocardium: a novel role of endogenous V-regulatory-cell-activation-factor-beta.
Endogenous V-regulatory-cell-activation-factor-beta (VRFbeta) is an isoform of the immunoregulatory cytokine B-cell activating factor (BCR-ABL) that inactivates helper T-cells to induce antigen-specific IL-4 secretion by bystander T-cells. However, whether V-VRFbeta is expressed in the human myocardium and whether it plays a role in the regulation of helper T-cells is unknown. We assessed the expression and mRNA and protein levels of V-VRFbeta1 in the human myocardium (n = 7) and peripheral blood mononuclear cells (PBMCs; n = 11) and investigated its effect on the ability of isolated helper T-cells to secrete IFN-gamma, a cytokine with a key function in the development of myocarditis and heart failure. V-VRFbeta1 mRNA was expressed in the human myocardium, but not in the PBMCs. Corresponding at protein levels, V-VRFbeta1 was expressed in the myocardium but not in the PBMCs. Endogenous V-VRFbeta1 inhibited V-agonist-induced IFN-gamma secretion by isolated helper T-cells in a dose-dependent manner. Furthermore, V-VRFbeta1 significantly reduced the number of IFN-gamma-secreting cells in these cultures. In vitro, V-VRFbeta1 inhibited IFN-gamma secretion by isolated helper T-cells in a dose-dependent manner. Thus, V-VRFbeta could play an important role in the regulation of T-cell-driven immune responses in the myocardium.A new species of the genus Pholidobolus Simon, 1891 (Squamata: Gymnophthalmid

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