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[Effect of Polydatin on the myocardial fibrosis in patients with nonalcoholic fatty liver disease and type 2 diabetes].
To investigate the effect of Polydatin on the myocardial fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). A total of 80 patients were randomized into 2 groups, 40 cases in each group. The patients in group A were treated by oral administration of compound traditional Chinese medicine Decoction, while the patients in group B were treated with oral administration of Polydatin tablets. The levels of serum lipid, liver function, and myocardial fibrosis index (MFI) were examined, and the level of fasting blood glucose (FBG) was examined in group B. The levels of serum lipid and liver function were not significantly different between group A and B before treatment (P>0.05). After treatment, the level of FBG was significantly lower than that before treatment in group B, and the level of MFI was significantly higher than that before treatment in group A (P0.05). The level of MFI was significantly higher than that before treatment in group B (P0.05). Chinese medicinal compound Decoction has obvious effect in lowering blood glucose. Polydatin can improve the cardiac function of patients with NAFLD and T2DM.Alpha-1-antitrypsin in lung adenocarcinoma: in vitro studies suggest divergent functions between tumor and normal cells.
To evaluate the function of alpha-1-antitrypsin (AAT) in lung adenocarcinoma, we used a heterogeneous panel of cell lines to study the distribution of AAT, the functional roles of AAT by in vitro studies, and the effects of AAT on tumor cells. AAT was detected in all cell lines by immunohistochemical analyses, Western blotting, and enzyme-linked immunoassay. AAT, purified from the sera of healthy donors and patients with chronic obstructive pulmonary disease, inhibited growth of lung cancer cells grown in monolayer culture

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