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The Toll-like receptors (TLRs) are pattern recognition receptors mediating signalling upon the detection of microbial and viral products. The effects of these signalling molecules on immune cells are dependent on the context of disease and have been studied mainly in macrophages. Here, we investigate whether TLRs are also expressed in dendritic cells (DC), which orchestrate immune responses during the initiation of immunity and are essential for the elimination of intracellular pathogens. We found that DC express high levels of both TLR7 and TLR8 transcripts, at least in vitro. The TLR7 agonist imiquimod induces DC activation and maturation. The TLR8-specific agonist CL075 enhances the maturation of DC in vitro. The level of TLR8 mRNA expression was significantly higher than that of TLR7, suggesting that the TLR
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